大脑结构连接的改善伴随着肠道微生物群的变化,在结核性硬化症复杂小鼠模型中
Christine Chin-Jung Hsieh1, Yu-Chun Lo2,3, Hsin-Hui Wang2
1Biomedical Translation Research Center, Academia Sinica, Taipei, Taiwan.
Translational psychiatry
|January 31, 2024
概括
食库尔库通过改变肠道微生物群和髓蛋白质,改善了结核硬化综合体 (TSC) 小鼠的社会行为和大脑连接.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 微生物学 微生物学
背景情况:
- 结核性硬化综合体 (TSC) 是一种导致瘤和大脑功能障碍的遗传疾病.
- 自闭症谱系障碍 (ASD) 经常与TSC同时发生,与大脑连接功能受损有关.
- 食化合物如黄素和肠道微生物群影响神经功能.
研究的目的:
- 研究食中的黄素对Tsc2+/-小鼠的社会行为和大脑结构连接性的影响.
- 探索肠道微生物群在调解黄素对大脑网络完整性的影响中的作用.
- 为了检查黄素治疗后髓相关蛋白质的变化.
主要方法:
- 基于通道的扩散张力成像 (DTI) 来评估白质的完整性.
- 行为测试用于评估社会互动缺陷.
- 对肠道微生物群组成的分析.
- 测量髓相关蛋白质表达 (MBP,PLP).
主要成果:
- 黄素治疗改善了Tsc2+/-小鼠的异常社会行为.
- 在Tsc2+/-小鼠中,DTI显示脑网络连接性下降,黄素改善了这种情况.
- 库尔库改变了肠道微生物群的组成,与DTI指标相关的特定类型.
- 在黄治疗后,髓蛋白表达 (MBP,PLP) 增加.
结论:
- 食中的黄素可以改善TSC的小鼠模型中的社会缺陷和结构性大脑连接.
- 肠道微生物群的组成在观察到的神经改善中起作用.
- 黄素的治疗作用可能包括增强肠道细菌的髓化和调节.
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