孕产妇百日咳免疫接种和常规疫苗有效性的削弱:一个元分析和建模研究
Michael Briga1, Elizabeth Goult2, Tobias S Brett3,4
1Infectious Disease Epidemiology Group, Max Planck Institute for Infection Biology, Berlin, Germany. michbriga@gmail.com.
Nature communications
|January 31, 2024
概括
母亲免疫有效地保护新生儿免受 pertussis. 然而,目前的证据还不足以排除由于免疫弱导致的初级疫苗有效性的潜在长期降低.
科学领域:
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 百日咳 (百日咳) 控制优先保护过小的婴儿接种疫苗.
- 孕产妇免疫已经减少了婴儿百日咳,但可能会导致免疫力减弱,可能会影响初级疫苗的疗效.
- 现有的化研究对随访和统计能力有限.
结论:
- 孕产妇免疫接种仍然是保护脆弱新生儿免受 pertussis 的关键策略.
- 需要进一步的研究和长期跟踪,以最终评估母婴免疫对初级疫苗有效性的影响.
- 尽管有潜在的麻木,目前支持母婴免疫的公共卫生建议得到了持续新生儿保护的预测的支持.
更多相关视频
相关概念视频
Vaccinations
44.5K
Overview
44.5K
Development of Immunocompetence
309
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
309
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
287
Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
287
Active versus Passive Immunity
645
Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
Active Immunity
Active immunity refers to the resistance one develops...
645
Immunological Memory
616
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
616


