管理与alpelisib相关的高血糖和皮疹:使用Delphi技术的专家共识建议
Emily J Gallagher1, Heather Moore2, Mario E Lacouture3
1Division of Endocrinology, Diabetes and Bone Disease, Department of Medicine, and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Emily.Gallagher@mssm.edu.
NPJ breast cancer
|January 31, 2024
概括
与阿尔佩利西布一样,在酸-3-酶抑制疗法期间管理高血糖和皮疹需要专家的共识. 这些建议为有效的患者管理和改善临床结果提供了指导.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 内分泌学 在内分泌学.
背景情况:
- 酸-3-酶 (PI3K) 抑制剂,如alpelisib,与具有挑战性的不良事件有关,包括高血糖症和皮疹.
- 有效的管理策略对于患者的坚持和治疗成功至关重要.
研究的目的:
- 建立基于共识的建议,用于管理阿尔佩利西布治疗的患者的高血糖和皮疹.
- 为临床医生在临床实践中遇到这些不良事件提供实际指导.
主要方法:
- 召开了两个修改后的德尔菲小组,其中包括专家.
- 专家们在1到9的尺度上对各种管理干预措施的适当性进行了评价.
- 使用中位数和分散度来确定共识水平.
主要成果:
- 对于高血糖症,对于HbA1c6.5%至<8%或高风险的患者,如果他们有治疗前内分泌咨询,则开始使用alpelisib是合适的.
- 建议在基线HbA1c为5.7%至6.4%的患者使用预防性甲福明,它是首选的一线抗高血糖药物.
- 对于皮疹,建议使用预防性非镇静性H1抗组胺药物,这些药物以及局部类固醇是首选的初始治疗方法.
结论:
- 这些共识建议为PI3K抑制治疗期间管理高血糖和皮疹提供了框架.
- 这些指南旨在解决临床实践中的差距,并支持最佳的患者护理.
- 将这些建议与临床试验证据相结合,可以改善患者的治疗结果.
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