根据年龄组,在年轻的近视性玻璃眼患者中,玻璃眼的进展率不同
Eun Jung Lee1, Dongyoung Lee1, Min-Ji Kim2
1Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Scientific reports
|January 31, 2024
概括
患有近视正常张力玻璃眼 (NTG) 的年轻人经历了更快的疾病进展. 在近视NTG患者中,青光眼的进展随着年龄的增长而放缓,这凸显了年轻人早期干预的必要性.
科学领域:
- 眼科医生 眼科 眼科
- 玻璃眼研究研究 玻璃眼研究
- 近视研究 近视研究
背景情况:
- 正常张力玻璃眼 (NTG) 是玻璃眼的一种亚型,眼内压力保持在正常范围内.
- 与非近视患者相比,近视患者的NTG可能会呈现出不同的进展模式.
- 年龄是影响青光眼进展的已知因素,但其对近视NTG的具体影响需要进一步调查.
研究的目的:
- 调查近视正常张力玻璃眼 (NTG) 患者出现时的年龄和玻璃眼进展率之间的关系.
- 为了比较视网膜神经纤维层 (RNFL) 缺陷扩大率在近视NTG的不同年龄组.
- 为了指导临床管理,识别与年龄相关的潜在差异在青光眼的进展.
主要方法:
- 一项长期回顾性队列研究与近视性NTG患者进行.
- 患者在初始呈现时被分为三个年龄组:<30岁,30-39岁和40-49岁.
- 使用线性混合效应模型估计了RNFL缺陷宽度扩大的年率.
主要成果:
- 最年轻的年龄组 (<30岁) 显示RNFL缺陷进展的速度明显更快 (3.01°/年) 与老年组相比 (2.05°/年和2.06°/年).
- 在最年轻的队列中,这种加速的进展在随访的前10年内更加明显.
- 在最年轻的群体中,进展率呈现出随着年龄的增长而放缓的趋势.
结论:
- 这项研究提供了第一个证据,证明近视性NTG患者在年轻成年期内眼快速进展.
- 在近视NTG人群中,青光眼的进展似乎在老年人群中稳定下来.
- 临床医生应该意识到青光眼在较年轻的近视性NTG患者中可能具有攻击性的过程,并考虑量身定制的监测和治疗策略.
相关概念视频
01:25Glaucoma: Overview
573
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
573
01:27Open Angle Glaucoma: Treatment
452
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
452
01:28Angle Closure Glaucoma: Treatment
500
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
500
01:22Photoreceptors and Visual Pathways
6.0K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
6.0K