在细胞周期早期,SHR和SCR协调根系和生长
Cara M Winter1,2, Pablo Szekely3,4, Vladimir Popov5
1Department of Biology, Duke University, Durham, NC, USA. cara.winter@duke.edu.
Nature
|January 31, 2024
概括
转录因子SHORTROOT (SHR) 和SCARECROW (SCR) 控制植物根的发育. 它们在细胞周期早期的水平决定了细胞分裂的方向,协调了组织的模式和生长.
科学领域:
- 植物发育生物学
- 细胞动力学
- 基因监管网络
背景情况:
- 精确的细胞分裂对于多细胞生物的发展至关重要.
- 形成 (模式) 和增殖 (增长) 分区之间的协调仍然不清楚.
- SHORTROOT (SHR) 和SCARECROW (SCR) 是Arabidopsis根干细胞形成分裂的关键转录因子.
研究的目的:
- 研究SHR和SCR动态如何影响细胞分裂方向.
- 了解细胞分裂,模式和生长之间的协调机制.
- 挑战SHR-SCR基因调控网络的现有模型.
主要方法:
- 使用4D定量光表和共聚焦显微镜进行长期的SHR和SCR动态成像.
- 使用SHR诱导系统直接操纵转录因子水平.
- 根据动态SHR和SCR水平分析细胞分裂平面的方向.
主要成果:
- 细胞周期早期的SHR和SCR水平决定了细胞分裂是形成性的还是增殖性的.
- 观察到的SHR和SCR动力学不支持双稳定基因调节模型.
- 只有细胞周期早期的短暂,低水平的SHR和SCR才是形成分裂所必需的.
结论:
- 像SHR和SCR这样的发育调节器直接协调组织模式和生物的生长.
- 一个涉及细胞周期依赖转录因子水平的新机制调节细胞分裂方向.
- 这些发现为干细胞和植物发育提供了新的见解.
更多相关视频
08:36Generation of Integration-free Human Induced Pluripotent Stem Cells Using Hair-derived Keratinocytes
Published on: August 20, 2015
11.6K
14:192D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development
Published on: March 25, 2022
3.9K
相关概念视频
Cells Coordinate Growth and Proliferation
4.5K
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
4.5K
Determining the Plane of Cell Division
3.3K
Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function.
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division...
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division...
3.3K
The Cell Cycle Control System
2.9K
The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
2.9K
S-Cdk Initiates DNA Replication
4.7K
The cell cycle is a series of events leading to DNA duplication followed by the division of cell content to form two daughter cells. The cell cycle progresses in four stages—the cell increases in size (gap 1 or G1-phase), duplicates its DNA (synthesis or S-phase), prepares to divide (gap 2 or G2-phase), and divides (mitosis or M-phase).
Two states at the origin of replication
In eukaryotes, the initiation of replication occurs at many sites on the chromosomes, called the origins of...
Two states at the origin of replication
In eukaryotes, the initiation of replication occurs at many sites on the chromosomes, called the origins of...
4.7K
Separation of Sister Chromatids
3.6K
At the transition from prophase to metaphase, there is a reduction in cohesion along the chromosomal arms, resulting in the resolution of sister chromatids. However, residual cohesin connections remain to hold the sister chromatids together until the transition from metaphase to anaphase. The residual connection prevents any premature separation of sister chromatids, blocking the risks of aneuploidy within the daughter cells.
At the onset of anaphase, separase, a proteolytic enzyme, is...
At the onset of anaphase, separase, a proteolytic enzyme, is...
3.6K
Negative Regulator Molecules
35.4K
Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
35.4K
