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Necrosis01:16

Necrosis

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Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
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7-脱水胆固醇决定了铁的敏感性

Yaxu Li1,2, Qiao Ran1,2, Qiuhui Duan1,2

  • 1Tongji University Cancer Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.

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概括

细胞死亡过程 - - 铁灭是由胆固醇生物合成调节的. 7 - 脱水胆固醇 (7- DHC) 作为抗铁化代谢物,在癌症和缺血再输液损伤方面具有治疗潜力.

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科学领域:

  • 生物化学
  • 细胞生物学
  • 代谢过程

背景情况:

  • 铁,一种依赖于铁的细胞死亡,与癌症和缺血再输液损伤 (IRI) 等疾病有关.
  • 胆固醇生物合成途径对于细胞功能和完整性至关重要.

研究的目的:

  • 研究远端胆固醇生物合成酶在调节铁质中的作用.
  • 识别关键代谢物和参与铁死控制的途径.

主要方法:

  • 全基因组CRISPR-Cas9查以确定调节铁的基因.
  • 代谢物分析以量化7-脱水胆固醇 (7-DHC) 的水平.
  • 在胆固醇生物合成途径中抑制和激活特定的酶.

主要成果:

  • 酶MSMO1,CYP51A1,EBP和SC5D可以抑制铁,而DHCR7则可以促进铁.
  • 通过防止脂自氧化,7- 脱胆固醇 (7- DHC) 作为内源性抗铁代谢物起作用.
  • 抑制EBP会诱导铁死并减少瘤的生长;抑制DHCR7会促进癌症转移并减轻脏IRI.

结论:

  • 7- 脱水胆固醇 (7- DHC) 是一种天然的抗铁化代谢物.
  • 针对7-DHC生物合成途径为癌症和IRI提供了一个有前途的治疗策略.