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亲生繁殖抑郁症与比利时蓝牛肉牛的近期同卵性血统细分相关

Maulana Mughitz Naji¹, José Luis Gualdrón Duarte^2,3, Natalia Soledad Forneris²

¹Unit of Animal Genomics, GIGA-R & Faculty of Veterinary Medicine, University of Liège, Quartier Hôpital, Avenue de l'Hôpital, 11, 4000, Liege, Belgium. mnaji@uliege.be.

Genetics, selection, evolution : GSE

|January 31, 2024

概括

最近的近亲繁殖对牛的特征产生了重大影响,最近的同卵性血统段显示出比古代更强烈的近亲繁殖抑郁症. 交配计划应优先考虑管理最近的近亲繁殖水平,以改善牛的健康和表现.

科学领域:

动物遗传学动物遗传学
量化遗传学量化遗传学
畜牧养殖畜牧养殖畜牧养殖

背景情况:

牛群中的高近亲繁殖水平可能会导致近亲繁殖抑郁症 (ID).
了解ID需要准确估计内生系数 (F).
区分最近与古代近亲繁殖的影响对于有效的繁殖策略至关重要.

研究的目的:

为了比较不同的内生系数 (F) 估计器对它们对等位基频率的敏感性.
评估最近与古代近亲繁殖对牛表现特征的影响.
确定最可靠的方法来评估家畜的近亲繁殖抑郁症.

主要方法:

利用了来自14,205头比利时蓝牛的基因型数据.
计算了五个亲生生殖系数估计器:F_PED,F_UNI,F_GRM,F_HET,以及F_HBD.
分析了11个线性分类特征,并按年龄分类了同卵性按血统 (HBD) 的细分.

主要成果:

F_UNI和F_GRM对等位基频率选择敏感,而F_HET和F_HBD则更强大.
在四个特征 (身高,长度) 中检测到显著的内生抑郁症,F_HBD和F_UNI显示出最强的关联.
最近的HBD片段 (大约15代内的共同祖先) 显示出比古代HBD片段更强的ID.

结论:

突变负载似乎随着哈普洛型年龄的增长而减少.
最近的近亲繁殖水平比古代的近亲繁殖对近亲繁殖抑郁更为关键.
牲畜交配计划应主要侧重于管理最近的近亲繁殖,以减轻负面影响.

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