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在良性上皮质质性病变中,YAP是否会影响细胞增殖和细胞亡?

Rani Iani Costa Gonçalo¹, Julliany Taverny Sousa¹, Carla Samily de Oliveira Costa¹

¹Department of Oral Pathology, Federal University of Rio Grande do Norte, Natal, Brazil.

|February 1, 2024

概括

YAP蛋白的表达在牙病原性角囊中最高,并且与某些牙病原性病变中的细胞增殖标记相关,这表明它在病变进展中发挥了作用.

科学领域:

口腔病理学口腔病理学
分子生物学分子生物学
在瘤学瘤学.

背景情况:

牙病变包括一系列良性和恶性瘤和囊.
河马信号通路,特别是YAP (Yes-associated protein) 蛋白,与组织稳态和癌症有关.
了解良性牙病变中的YAP表达对于阐明它们的发病因子至关重要.

研究的目的:

为了研究YAP的免疫组织化学表达.
为了将YAP表达与细胞增殖 (Ki-67,cyclin D1) 和细胞亡 (Bcl-2) 标志物相关联.
分析这些相关性在各种良性上皮质 odontogenic 病变.

主要方法:

分析了95个牙病变 (牙囊,牙细胞囊,乳腺母细胞瘤) 和10个牙毛囊.
针对YAP的免疫组织化学,环素D1,Ki-67和Bcl-2.
具有统计评估的定性和定量免疫表达分析.

主要成果:

最高的YAP表达发现在口腔瘤中,其次是乳腺母细胞瘤.
在牙状囊和单囊性乳腺母细胞瘤中观察到YAP和cyclin D1之间的显著正相关性.
在单囊性乳腺母细胞瘤中,YAP与Ki-67也有正相关性;没有发现与Bcl-2的相关性.

结论:

在不同的牙病变中,YAP的表达有所不同.
YAP可能在上皮细胞增殖中发挥作用,引起瘤和瘤的发生.
这些发现表明YAP可能与牙病变的进展有关.

关键词:

灭症 (apoptosis) 是一种死亡的过程.细胞的增殖细胞的增殖.免疫组织化学免疫组织化学牙产生的囊 (odontogenic cysts) 是一种引起牙的疾病.臭氧致癌瘤的发生是的 - 相关蛋白质.

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