心理药物的流行,模式和对爱尔兰智力障碍老年人认知和身体功能的影响:纵向队列研究,2009-2020年
Marina Odalović1, Ashleigh Gorman1, Aviejay Paul2
1School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Ireland; and Trinity Centre for Ageing and Intellectual Disability, Trinity College Dublin, Ireland.
BJPsych open
|February 1, 2024
概括
在智力障碍的老年人中,心理药物的使用在10年内仍然很高,抗抑郁药的使用增加,但焦虑和催眠药的处方减少. 多药与日常生活中的依赖有关.
科学领域:
- 老年学是指老年学的学科.
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 智力障碍 (ID) 的老年人经常使用精神药物,并经验多药.
- 密切监测心理药物处方是必不可少的,在这个人群中,由于高患病率.
研究的目的:
- 分析ID的老年人中使用心理药物和多药物的趋势.
- 确定十年来与精神药物使用相关的预测因素和健康结果.
主要方法:
- 在2009/2010至2019/2020年期间,参与所有四个波段的爱尔兰老龄化长度研究 (IDS-TILDA) 智力障碍补充的智力障碍成年人 (≥40岁) 的长度研究.
- 统计分析包括Cochran的Q测试,McNemar-Bowker测试和概括估计方程模型来评估变化和关联.
主要成果:
- 整体心理药物使用 (61.2-64.2%) 和多药 (42.7-38.3%) 在10年内没有显著变化.
- 抗精神病药物的患病率保持稳定 (47.6-44.6%),而抗焦虑药物和催眠药物的患病率显著下降.
- 抗抑郁药的使用量显著增加 (28.6-35.8%),情绪稳定剂的使用量也显著增加 (11.5-14.6%).
- 心理药物多药与日常活动中依赖性增加有关 (OR = 1.80).
结论:
- 尽管特定药物类别的变化,总体上,精神药物处方和多药在ID的老年人中仍然很高.
- 增加抗抑郁药的使用和持续高的抗精神病药物使用率突出显示了正在进行的药物管理挑战.
- 多药和功能依赖之间的关联强调了这种脆弱群体中与药物相关的伤害风险.
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