变化的静态和动态大脑功能拓组织在患有甲状腺障碍视觉神经病变的患者
Jiang Zhou1, Wen Chen2, Wen-Hao Jiang1
1Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, China.
The Journal of clinical endocrinology and metabolism
|February 1, 2024
概括
大脑网络的变化与类甲状腺视神经病变 (DON) 有关,这是甲状腺相关眼科医症 (TAO) 的视力威胁. 这些改变的功能连接体可能作为疾病进展的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 眼科医生 眼科 眼科
背景情况:
- 甲状腺视神经病变 (DON) 是甲状腺相关眼科医症 (TAO) 的严重并发症,对视力构成重大风险.
- 了解DON的神经机制对于早期临床诊断和管理至关重要.
研究的目的:
- 为了研究TAO患者的静态和动态功能性脑网络的变化,有和没有DON.
- 探索功能连接体异常与DON的存在和严重程度之间的关系.
主要方法:
- 一项涉及66名TAO患者 (28名DON,38名非DON) 和30名健康对照 (HC) 的横截面研究.
- 静态功能磁共振成像 (rs-fMRI) 与图形理论分析相结合,以评估网络的拓性质.
- 评估静态 (例如,全球效率,特征路径长度) 和动态 (例如,效率差异) 网络指标.
主要成果:
- 与DON患者相比,DON患者的全球效率,局部效率,聚类系数和小世界性降低,与HC相比,特征路径长度增加.
- 在DON和非DON患者中观察到结节网络属性的异常,在DON组中观察到轨道前皮层和视觉网络的特定变化.
- 动态分析显示,在DON组中,总效率和特征路径长度的差异较大. 在DON患者中发现了一个强化的视觉网络子网络.
- 网络属性与临床变量有显著的相关性,静态/动态指标组合显示了DON的最佳诊断性能.
结论:
- 在TAO患者中,大脑功能网络存在显著的变化,无论是有DON还是没有DON.
- 这些发现为DON的神经基础提供了新的见解.
- 功能网络属性显示出作为跟踪TAO从非DON到DON阶段的进展的生物标志物的潜力.
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