初级失眠患者的症状和认知功能变化之间的相关性以及肠道微生物群的途径
Linghui Nie1, Qian Xiang2, Yaqi Lin1
1Children's Behavioral Development Rehabilitation Center, The Second People's Hospital of Guangdong Province, Guangzhou, Guangdong, China.
Biochemistry and biophysics reports
|February 1, 2024
概括
这项研究揭示了肠道微生物群的组成与初级失眠 (PI) 症状和认知功能有关. 肠道中的特定代谢途径可能会影响PI患者的睡眠质量和严重程度.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 代谢学 代谢学 代谢学
背景情况:
- 初级失眠 (PI) 的特点是睡眠障碍,病因和发病原因不明.
- 肠道微生物群在精神障碍中的作用已得到认可,但其在PI中的特定机制在很大程度上仍未知.
研究的目的:
- 探索肠道微生物群与原发性失眠患者的症状和认知功能变化之间的关系.
主要方法:
- 便16S rRNA基因测序被用来描述PI患者和健康对照的肠道微生物群.
- 重量基因共同表达网络分析 (WGCNA) 构建了共同发生的网络.
- PICRUSt2软件预测了与肠道微生物群相关的基因和基因组京都百科全书 (KEGG) 途径.
主要成果:
- WGCNA确定了与失眠症状相关的操作分类学单元 (OTU) 模块.
- 预测的代谢途径,如胰岛素信号和黄类生物合成,与睡眠效率和严重程度有关.
- 其他途径,如氨酸代谢和氨酸代谢与总睡眠时间和认知变化 (MoCA分数) 相相关.
结论:
- 在PI患者中,肠道微生物群的组成发生了显著的变化.
- 肠道微生物群中的特定代谢途径可能与关键的失眠特征有关,包括睡眠质量,严重程度和认知功能.
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