生物医学研究是否可以自我纠正? 建模对虚假科学持续存在的见解
1School of Medicine, Trinity College, Dublin, Ireland.
Royal Society open science
|February 1, 2024
概括
生物医学研究中的可复制性是一个主要问题,导致资源被浪费. 这项研究模拟了出版生态系统,以了解影响研究浪费和可信度的因素,并提供了潜在的解决方案.
科学领域:
- 生物医学研究的完整性
- 科学出版生态系统
- 研究可复制性研究可复制性
背景情况:
- 发表的大量生物医学研究缺乏可重复性,破坏了科学信任,导致大量的研究浪费.
- 科学的自我纠正性在哲学上是公认的,但缺乏关于纠正虚假发现所需的努力和时间的经验理解.
- 出版生态系统中的激励措施优先考虑新的积极结果,而不是无效的发现,阻碍了自我纠正过程,并掩盖了影响科学完整性的因素.
研究的目的:
- 开发出版物生态系统的简单模型,分析影响研究浪费,可信度,纠正力度和纠正时间的因素.
- 确定生物医学科学在哪些条件下可以有效地自我纠正,以及当纠正性出版物本身是不够的.
- 建模和评估潜在的缓解策略,以提高发表的科学发现的可靠性.
主要方法:
- 开发一个模拟科学出版物生态系统动态的数学模型.
- 探索特定领域虚假阳性率和时间延迟对研究浪费和纠正工作的影响.
- 模拟各种由研究人员和出版商驱动的干预措施,以评估它们在缓解不值得信赖的结果方面的有效性.
主要成果:
- 研究浪费和纠正所需的努力受到特定领域的错误阳性率和发布纠正结果的延迟的影响.
- 该模型确定了生物医学研究生态系统表现出自我纠正能力的特定条件.
- 该研究揭示了一些情景,即不值得信赖的结果的传播不能仅仅通过发表纠正性研究来阻止.
结论:
- 科学自我纠正的可靠性和效率严重取决于错误阳性率和纠正研究传播的速度.
- 了解出版生态系统的动态对于制定有效的战略来提高生物医学研究的可靠性至关重要.
- 针对研究人员和出版商的行为进行有针对性的干预是必要的,以减少研究浪费和提高发表科学的整体完整性.
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