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Updated: Jun 20, 2026

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells
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产生人类iPSC衍生的心肌细胞/纤维细胞工程心脏组织模型

Max J Cumberland1, Jonas Euchner1,2, Amar J Azad1

  • 1Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, England, B15 2TT, UK.

F1000Research
|February 1, 2024
PubMed
概括

使用人类诱导的多能干细胞衍生的心肌细胞 (hiPSC-CMs) 和心脏纤维细胞 (hiPSC-CFs) 的工程心脏组织模型为研究心脏病提供了动物模型的有希望的替代方案. 这些3D模型更好地模仿了心脏的微环境.

关键词:
3D心脏模型 3D心脏模型工程心脏组织 (EHT)心脏共同培养的心脏共同培养的心脏纤维化.诱导多能干细胞衍生的心脏纤维细胞 (iPSC-CF).诱导多能干细胞衍生的心肌细胞 (iPSC-CM)

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...