功能性脂质纳米粒子的进步:从药物输送平台到临床应用
Manikandan Dhayalan1,2, Wei Wang3, S U Mohammed Riyaz1,4
1Department of Prosthodontics, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences (Saveetha University), Chennai, Tamil Nadu 600 077 India.
3 Biotech
|February 1, 2024
概括
脂质纳米颗粒是多功能纳米载体,具有已证明的治疗效果,特别是用于核酸输送. 需要进一步的研究才能充分实现它们在药物输送中的临床潜力.
科学领域:
- * 纳米技术的使用
- * 制药科学 制药科学
- * 材料科学 材料科学
背景情况:
- * 脂质纳米颗粒 (LNP) 自从Doxil于1995年获得批准以来,已经显示出显著的治疗效果.
- *RNA治疗和mRNACOVID-19疫苗的成功凸显了LNP在核酸输送方面的潜力.
- *LNP是多功能纳米载体平台,在各种行业都有应用.
研究的目的:
- *审查不同类型的脂质纳米颗粒及其历史发展.
- *概述脂质纳米颗粒的各种合成方法,包括高压均质化 (HPH).
- * 讨论LNP在药物输送中的表征和应用,特别是对于核酸和小分子.
主要方法:
- * 关于脂质纳米粒子合成和应用的现有文献的审查.
- *讨论合成技术,如高压均质化 (HPH),微乳液方法和基于溶剂的技术.
- *对LNP合成所涉及的四个一般步骤的概述,并注意到脂质分散的不可预测性.
主要成果:
- * 识别各种LNP类型 (如脂质体,固体脂质纳米粒子) 和它们的演变.
- *详细描述多种合成方法,其中HPH是最常见的.
- * 探索LNP的应用,包括用于质母细胞瘤的拉巴素涂层LNP以及用于抗癌核酸输送的结合剂.
结论:
- *脂质纳米颗粒具有高生物相容性,易于生产,可扩展性,无毒性和量身定制的分布.
- *尽管目前存在限制,但作为药物输送工具,LNP显示出巨大的前景.
- * 为了充分释放脂质纳米颗粒的临床和治疗潜力,继续进行研究至关重要.
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