在消化道瘤中m6A调节者的修饰模式和代谢特征
Bing He1, Yiyang Hu1, Hui Chen1
1Department of Gastroenterology, Xinqiao Hospital, Army Military Medical University, Chongqing, 400037, China.
Heliyon
|February 1, 2024
概括
N6-甲基氨酸 (m6A) 调节剂对消化道瘤产生影响. 它们独特的表达模式与患者的预后,代谢重编程和化疗敏感性相关,突出显示m6A作为潜在的预后标志物.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 癌症研究 癌症研究
背景情况:
- N6-甲基氨酸 (m6A) 是一种关键的表观遗传修饰,涉及各种生物过程,包括癌症的发展和进展.
- 在不同类型的瘤中观察到m6A调节者的异常表达,这表明它在瘤发生中起作用.
研究的目的:
- 为了研究消化道瘤中m6A调节者的差异表达模式.
- 探索m6A调节器表达,患者预后和消化道癌症中的代谢重编程之间的相关性.
- 评估m6A调节器作为化学疗法敏感性预测标记物的潜力.
主要方法:
- 来自消化道瘤患者公共数据库的转录表达数据和临床信息的分析.
- 根据m6A调节器表达模式对患者进行分组.
- 生存分析,以评估群体之间的预后差异.
- 功能丰富分析以确定相关的生物途径,包括新陈代谢.
主要成果:
- 基于m6A调节器表达形状,确定了消化道瘤患者的不同集群.
- 在这些m6A定义的集群中观察到患者生存率的显著差异.
- 发现m6A表达模式与能量和核酸代谢途径重叠.
- 功能分析表明,m6A的修改可能会驱动癌细胞中的代谢重编程以支持增殖.
结论:
- m6A调节剂在消化道瘤的发生和进展中起着重要作用.
- m6A表达特征可以根据预后对患者进行分层,并预测化疗敏感性.
- m6A修饰驱动的代谢重编程是消化道癌症的关键特征,提供潜在的治疗点.
相关概念视频
03:03mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
02:23Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
02:23Master Transcription Regulators
6.9K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
6.9K
01:37Epigenetic Regulation
3.0K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.0K
01:22MicroRNAs
3.0K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K