生物药物保护牛皮病患者免受COVID-19感染加剧
Yu-Xin Zheng1, Xi-Bei Chen1, Zhao-Yuan Wang1
1Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Heliyon
|February 1, 2024
概括
COVID-19 感染可以使牛皮症状恶化. 生物治疗方法,特别是ixekizumab,可能会防止牛皮的恶化,这表明在疫情期间继续使用是有益的.
科学领域:
- 免疫皮肤学 免疫皮肤学
- 病毒免疫学 病毒免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 牛皮患者在COVID-19感染后可能会出现症状爆发.
- 中国从"零COVID"政策的转变导致Omicron感染的激增.
- 了解COVID-19对牛皮的影响对于患者管理至关重要.
研究的目的:
- 为了调查COVID-19患者的牛皮恶化.
- 评估阿达利穆马布,塞库金努马布和伊克西祖马布对COVID-19后的牛皮病爆发的影响.
- 评估血清OAS1,OAS2和OAS3水平的变化,与生物药物和感染有关.
主要方法:
- 从2022年11月到2023年2月,对209名牛皮患者进行前性研究.
- 定义牛皮恶化为牛皮区域和严重性指数 (PASI) >0后COVID-19的变化.
- 评估严重恶化 (PASI >3) 和测量血清OAS1,OAS2和OAS3水平.
主要成果:
- 在COVID-19感染后,一些患者的牛皮病严重程度恶化.
- 与非生物药物使用者相比,使用生物药物的患者发生牛皮恶化的情况较少.
- 伊克西祖马布显示具有统计学显著的保护作用 (p < 0.05);阿达利穆马布和塞库金乌马布没有达到显著性.
- 生物抑制了血清OAS2/OAS3和提高了OAS1水平.
结论:
- 生物药物可能在COVID-19感染的牛皮患者中发挥保护作用.
- 在COVID-19大流行期间,建议在牛皮患者中继续使用生物药物.
- 进一步研究生物药物对病毒感染的免疫调节作用是有必要的.
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