侵入性创伤重新体验领域:ENIGMA PTSD联盟的功能连接特征分类
Benjamin Suarez-Jimenez1, Amit Lazarov2,3, Xi Zhu3
1Del Monte Institute for Neuroscience, Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, New York.
Biological psychiatry global open science
|February 1, 2024
概括
休息状态功能连接 (rsFC) 可以区分创伤暴露的个体与患有PTSD或侵入性创伤重现领域 (ITRED) 的个体. 然而,rsFC并没有有效地区分PTSD与仅ITRED的组.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 计算精神病学是一种计算精神病学.
背景情况:
- 侵入性创伤重复体验领域 (ITRED) 是一个新概念,重点关注创伤后精神病理学中的非自愿重复体验症状.
- ITRED提出了一个关于创伤后应激障碍 (PTSD) 研究的新视角,强调侵入性记忆,梦和回忆.
研究的目的:
- 调查与侵入性创伤再体验领域 (ITRED) 相关的神经网络连接模式.
- 探索休息状态功能连接 (rsFC) 在对患有PTSD,仅ITRED和仅暴露于创伤 (TE) 的个体进行分类时的实用性.
主要方法:
- 利用了来自ENIGMA PTSD联盟9个站点的584名参与者的静止状态功能连接 (rsFC) 数据.
- 采用机器学习方法 (随机森林分类) 来区分基于rsFC签名的PTSD,ITRED-only和TE-only组.
- 使用交叉验证和独立测试数据集验证的分类模型性能,评估曲线下的面积 (AUC).
主要成果:
- rsFC的签名在区分TE-only参与者和PTSD和ITRED-only组之间实现了约60%的准确性.
- 使用rsFC,试图区分PTSD和ITRED-only个体时,分类准确性较低 (45%).
- 默认模式网络 (DMN) 路径是区分TE-only参与者与PTSD和ITRED-only组的共同特征,而前对对联网络连接显示出独特的区分模式.
结论:
- 神经网络连接为对创伤后精神病理学的分类提供了基于神经生物学的基础,支持ITRED作为一个独特的领域.
- 结果表明rsFC可以区分一般的创伤暴露与特定的创伤后症状集群,但区分PTSD和ITRED需要进一步调查.
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