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体发育的分子机制:一个四步之旅

Maria Gavrish¹, Angelina Kustova¹, Juan C Celis Suescún¹

¹Laboratory of Genetics of Brain Development, Research Institute of Neurosciences, Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia.

Frontiers in neuroanatomy

|February 1, 2024

概括

体 (CC) 连接大脑半球,其发育涉及四个阶段. 本综述详细介绍了指导CC轴突形成和指导的分子机制.

科学领域:

神经科学是一个神经科学.
发展生物学发展生物学
神经解剖学是一个神经解剖学.

背景情况:

体 (Corpus Callosum,简称CC) 是一个关键的白质通道,连接着胎盘哺乳动物的大脑半球.
它包括大约80%的人类大脑中所有 commissural 轴突.
CC的发展是一个复杂的过程,涉及复杂的分子信号.

研究的目的:

为了提供一个深入的四个发育阶段的骨轴突形成的深入审查.
识别和描述影响CC发展每个阶段的关键分子因素.
提供关于状轴突从发育到突触形成的指导机制的见解.

主要方法:

关于体发育的研究的文献综述.
对调控轴突发生和指导的分子和细胞机制的分析.
综合了关于CC形成的四个不同阶段的信息.

主要成果:

状轴突的发展分为四个主要阶段:轴突的规范和迁移,捆绑导航,中线交叉和向.
众多的细胞内和细胞外分子因素协调每个发育阶段.
了解这些分子参与者对于理解CC形成至关重要.

结论:

体的发展是一个高度规范的,多阶段的过程.
分子信号通路对于引导状轴突在发育过程中至关重要.
对这些途径的进一步研究可以阐明大脑连接障碍背后的机制.

关键词:

轴突指导和可塑性大脑发育大脑的发育大脑的发展卡洛索尔是发射神经元的发射神经元.身体的质体 (callosum) 是一个体.皮质的中线是皮质的中线.新皮质新皮质的新皮质

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