NcRNA:听力损失的关键和潜力
Keyu Zhu1, Ting Wang2, Sicheng Li3
1Department of Plastic and Cosmetic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Frontiers in neuroscience
|February 1, 2024
概括
非编码RNA,如微RNA和长链非编码RNA,是听力损失发展的关键参与者. 了解这些分子为精确的听力损失治疗提供了新的途径.
科学领域:
- 遗传学 是一个遗传学.
- 分子生物学分子生物学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 听力损失是一个全球性的健康问题,具有重大的社会经济影响.
- 表观遗传机制,包括非编码RNA (ncRNA),越来越多地被认为是听力损失的病原体.
- 非编码RNAs调节关键的细胞过程,影响疾病的进展.
研究的目的:
- 在听力损失的背景下,提供ncRNAs,特别是微RNAs (miRNAs) 和长链非编码RNAs (lncRNAs) 的全面审查.
- 探索ncRNAs在听力损失背后的分子机制中的作用.
- 确定听力损失治疗中ncRNA研究的当前挑战和未来方向.
主要方法:
- 关于ncRNAs和听力损失的研究的文献综述.
- 对miRNAs和lncRNAs在细胞代谢和死亡途径中与听力损失相关的调节功能的分析.
- 关于ncRNAs参与听力损失的开始和进展的信息的综合.
主要成果:
- ncRNAs,包括miRNAs和lncRNAs,广泛参与调节基因表达和蛋白质相互作用.
- 这些ncRNAs调节细胞代谢和细胞死亡,直接影响听力损失的发生和预后.
- 特定的miRNAs和lncRNAs已被确定为各种形式的听力损失的关键调节者.
结论:
- ncRNAs代表了理解和治疗听力损失的一个有希望的领域.
- 对ncRNAs的特定作用和治疗潜力的进一步研究是有必要的.
- 解决目前的研究缺口将促进开发精确的,基于ncRNA的听力损失治疗策略.
相关概念视频
02:39lncRNA - Long Non-coding RNAs
8.6K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K
01:20Types of RNA
5.8K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
RNA Performs Diverse...
5.8K
01:22Hair Cells
40.5K
Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
40.5K
02:41Chromatin Structure Regulates pre-mRNA Processing
7.0K
In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...
The chromatin structure, especially...
7.0K
02:15Experimental RNAi
6.1K
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
6.1K
01:31Transducer Mechanism: Nuclear Receptors
1.3K
Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
1.3K