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Updated: Jul 4, 2025

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可切换复合物的细胞核透和单一氧释放的光学调制

Zakaria Ziani1, Saioa Cobo1, Nathalie Berthet1

  • 1University Grenoble Alpes, CNRS, DCM, 38000 Grenoble, France.

iScience
|February 1, 2024
PubMed
概括

研究人员开发了一种可光激活的复合物 (DHP-Pt),在暴露在红光下,在癌细胞核内产生细胞毒性单片氧. 这种新的方法通过将治疗剂直接输送到瘤细胞,提供向癌症治疗.

关键词:
生物科学 生物科学化学 化学 化学物理 物理学 物理

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Irradiation of a spin-active nucleus causes an increase or decrease in the signal intensity of neighboring nuclei that are not necessarily chemically bonded or involved in J-coupling.  This phenomenon, called the Nuclear Overhauser Enhancement (NOE), results from through-space interactions between the nuclear spins. The NOE effect decreases with increasing internuclear distance and is generally not observed beyond 4 angstroms. In NOE, dipole-dipole interactions between neighboring...
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