相关实验视频
Updated: Jul 4, 2025

08:22
A Preclinical Model of Exertional Heat Stroke in Mice
Published on: July 1, 2021
3.8K
在炎热环境中进行体力劳动时,减轻急性损伤风险的策略
Abdulaziz Masoud1, Zachary J McKenna2, Zidong Li3
1Health, Exercise and Sports Sciences, University of New Mexico, Albuquerque, NM, United States.
American journal of physiology. Renal physiology
|February 1, 2024
概括
在炎热的环境下工作会增加损伤的风险. 本综述探讨了在体力苛刻的工作中预防急性损伤 (AKI) 和慢性病 (CKDnt) 的策略.
科学领域:
- 环境健康 环境健康
- 腎臟病學 (nephrology) 是一種醫學.
- 职业医学 职业医学是专业的.
背景情况:
- 在炎热的环境中长时间体力劳动会损害功能,增加急性损伤 (AKI) 风险.
- 气候变化加剧了户外工作者的热压力,特别是在农业和建筑行业.
- 气温上升与非传统起源慢性病 (CKDnt) 的增加有关,可能来自复发性AKI发作.
研究的目的:
- 审查和提出预防和减轻AKI风险的战略.
- 为了解决暴露在热量的健康影响,功能在体力苛刻的职业.
主要方法:
- 对热应激,体力劳动,脱水和损伤研究的文献综述.
- 关于职业热暴露与脏疾病发展之间的关系的综合证据.
- 识别热引起的AKI的预防和缓解策略.
主要成果:
- 由于热和脱水而导致的反复发生的AKI可能会导致永久性损伤和CKDnt.
- 职业热暴露对脏健康构成重大风险.
- 有证据表明,需要采取积极的干预措施来保护工人.
结论:
- 实施预防策略至关重要,以减少热暴露工人的AKI风险.
- 缓解热应激可以防止损伤和CKDnt的发展.
- 需要进一步的研究和干预措施来保护职业环境中的脏健康.
相关概念视频
Methods of reducing fever
664
The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
Pharmacological Methods of Reducing Fever:
664
Heart Failure Drugs: Diuretics
381
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
381
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
431
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
431
Renal Tubule and Collecting Duct
986
The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
986
Decreased Body Temperature
618
A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
618
Regulation of Water Intake
506
Osmolality refers to the number of solute particles per kilogram of solvent in a solution. Plasma osmolality specifically indicates the total number of solute particles per kilogram of water in blood plasma. This value reflects the body's hydration status and is tightly regulated through mechanisms controlling water intake and output. While water consumption is a conscious decision, the body has intrinsic regulatory systems to maintain fluid balance. Dehydration, a state of water deficit...
506

