在管管中FABP4的高表达是DKD患者预后不佳的危险因素
Yao Huang1,2, Xinyuan Cui1,2, Zheng Li1,2
1Department of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Current medicinal chemistry
|February 1, 2024
概括
糖尿病病中脂肪酸结合蛋白4 (FABP4) 的高表达与损伤和预后不佳有关. 管体和炎症细胞中FABP4的增加表明末期病 (ESRD) 的风险更高.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 分子生物学分子生物学
背景情况:
- 不平衡的脂质代谢有助于糖尿病病 (DKD) 的管损伤.
- 脂肪酸结合蛋白4 (FABP4) 与细胞脂质毒性有关.
- 在DKD脏组织中FABP4表达及其临床相关性仍未得到研究.
研究的目的:
- 为了研究DKD患者脏组织中的FABP4表达.
- 分析FABP4与临床和病理参数的相关性.
- 评估FABP4作为DKD预后的预测因素.
主要方法:
- 108名患者的回顾性队列研究 (70名DKD,38名NDKD).
- 通过ELISA测量血清/尿液FABP4;通过免疫组织化学测量脏管间FABP4.
- 评估FABP4+巨细胞和统计分析,包括相关性,回归,ROC和生存曲线.
主要成果:
- 患有DKD的患者表现出高脏FABP4表达和子宫外脂肪沉积.
- 管FABP4与尿中的白蛋白与肌素比率 (UNAG) 和末期病 (ESRD) 风险正相关.
- 在管体和炎症细胞中高FABP4表达独立预测了DKD中ESRD风险的增加.
结论:
- 增加FABP4表达是DKD中管状脂质损伤的病原体的组成部分.
- 在DKD患者中,FABP4作为预测不良预后和ESRD的重要生物标志物.
- 针对FABP4可能为DKD管理提供治疗潜力.
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