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在Von Hippel-Lindau相关的清细胞脏细胞癌中进行非侵入性瘤等级评估:基于磁共振成像的研究

Aryan Zahergivar¹, Pouria Yazdian Anari¹, Neil Mendhiratta²

¹Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.

Journal of magnetic resonance imaging : JMRI

|February 1, 2024

概括

放射学分析显示,在Von Hippel-Lindau患者中,清细胞细胞癌 (ccRCC) 等级的非侵入性分类有潜力. 这种方法可以改善ccRCC的诊断和个性化治疗.

科学领域:

医疗成像医学成像
在瘤学瘤学.
放射学放射学是一门学科.

背景情况:

病理学分级对于清细胞细胞癌 (ccRCC) 的治疗和预后至关重要.
准确的分级助力个性化患者管理.

研究的目的:

用放射学来评估纹理分析,用于在Von Hippel-Lindau (VHL) 相关的ccRCC中对Fuhrman等级评估.
加强非侵入性诊断和为ccRCC患者量身定制的治疗策略.

主要方法:

对136名与VHL相关的ccRCC患者 (2010-2023) 的回顾性分析.
从1.5T和3TMRI扫描 (T1加权序列) 中提取的放射学特征.
一个堆叠模型 (随机森林和XGBoost) 开发用于预测瘤等级.

主要成果:

最好的模型在瘤等级分类方面达到0.79的准确性.
对于低级的ccRCC,敏感度为0.79和F1得分为0.86.
对于高等级的ccRCC,敏感度为0.78和F1得分为0.52.

结论:

放射学分析表明,在VHL相关的ccRCC中,对非侵入性病理学分级有希望.
这种技术可以提高诊断准确度和个性化治疗计划.

关键词:

清细胞细胞癌是什么?费尔曼的评级是如何评级的机器学习是机器学习.磁共振成像技术的使用无线电学 (radiomics) 是一种无线电学.希普尔 - 林达乌的时间.

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Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...