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吸烟对甲基化和精液参数的影响

Nasim Naeimi¹, Homa Mohseni Kouchesfehani², Zahra Heidari³

¹Department of Biology, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran.

Environmental and molecular mutagenesis

|February 1, 2024

概括

吸烟会诱导基因组DNA甲基化,这与男性不孕症有关. 这项研究发现,吸烟会改变CHD5基因甲基化,对精液质量产生负面影响,并增加男性不孕症风险.

科学领域:

表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
生殖生物学生殖生物学
毒理学毒理学毒理学

背景情况:

基因组DNA甲基化是一种与吸烟和男性不育相关的表观遗传修饰.
吸烟是已知的降低精液质量和男性不孕症的风险因素.

研究的目的:

研究吸烟,CHD5基因甲基化和不育男性的精液参数之间的关系.
确定CHD5基因甲基化是否可以作为精液质量和不孕症风险的生物标志物.

主要方法:

分析了224名男性的血液样本 (103名不育,121名生育),使用甲基化特异性PCR (MS-PCR).
在吸烟者和非吸烟者之间比较CHD5基因甲基化状态 (MM,MU,UU) 和精液参数.
评估了研究队列中甲基化水平,吸烟状态和不孕症之间的相关性.

主要成果:

在不育患者和对照组之间观察到CHD5基因甲基化状态的显著差异 (p < .001).
与非吸烟者相比,吸烟者表现出明显较低的平均精液参数,包括精子度 (32.21±5.27与55.27±3.38)).
在吸烟者 (22.5%) 与非吸烟者 (14.6%) 中发现CHD5基因的MM甲基化状态较高.

结论:

吸烟显著影响CHD5基因甲基化模式,导致吸烟者的甲基化水平更高,精液质量更差.
改变CHD5基因甲基化和吸烟者的精液参数减少表明评估男性不孕症风险的潜在生物标志物.
了解吸烟的这些表观遗传影响对于预测有害生殖结果和开发治疗策略至关重要.

关键词:

通过DNA甲基化.香烟吸烟 - - 吸烟是一件好事.不孕不育不孕不育不孕不育精液参数精液参数

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