艾滋病毒感染者心血管疾病的演变机制和表现:对管理的影响
Ilana Nazari1, Matthew J Feinstein1,2,3
1Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Clinical microbiology reviews
|February 1, 2024
概括
艾滋病毒感染者由于慢性炎症而面临更高的心血管疾病 (CVD) 风险. 管理策略对于解决艾滋病毒感染者的这些高风险至关重要.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 艾滋病毒感染者 (PWH) 对心血管疾病 (CVD) 的易感性增加,包括心肌梗塞和心力衰竭.
- 慢性免疫失调和持续的炎症是PWH的特征,特别是在持续的病毒病和CD4+T细胞恢复不良的情况下.
- 这种炎症状态,以及伴随的疾病,如失脂症和吸烟,显著促进PWH中心血管疾病的风险.
研究的目的:
- 审查PWH中心血管疾病风险增加的临床和机械学证据.
- 探索这群人群中特定心血管疾病表现的含义.
- 提供PWH中CVD的实际管理指南.
主要方法:
- 临床和机理学研究的文献综述.
- 分析证据,将艾滋病毒相关的炎症与心血管疾病联系起来.
- 综合当前的管理策略和不断变化的数据.
主要成果:
- 在PWH中持续的炎症是心血管疾病的主要驱动因素.
- 并发症和抗逆转录病毒治疗的副作用也会导致心血管疾病的风险.
- 特定的CVD表现在PWH中更为普遍.
结论:
- 了解炎症,并发症和治疗的相互作用是管理PWH中心血管疾病的关键.
- 积极的CVD风险评估和管理对于PWH至关重要.
- 随着数据的不断变化,需要对艾滋病毒感染者的心血管健康进行最新的临床指导.
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