阴极电压控制电刺激和贝塔丁可以从植入物表面去除医院病原体的污染
Tripti Thapa Gupta1, Bernadette Zumpano1, Jacob Opalinski1
1Garwood Medical Devices, LLC, Buffalo, New York, USA.
mSphere
|February 1, 2024
概括
阴极电压控制电刺激 (CVCES) 与贝塔丁相结合,有效地消除了骨科植入物上常见的周围假肢关节感染 (PJI) 生物膜. 这种方法对治疗耐药PJI具有前景,可能减少对多次手术和广泛使用抗生素的需求.
科学领域:
- 生物医学工程 生物医学工程
- 传染性疾病 传染性疾病
- 材料科学 材料科学 材料科学
背景情况:
- 周围假肢关节感染 (PJIs) 是整体关节整形术的重要并发症,通常需要复杂的治疗方案.
- 像*黄金葡萄球菌* (Staphylococcus aureus) *和*大肠杆菌* (Escherichia coli) *这样的细菌形成的生物膜使PJI中的抗生素有效性复杂化.
- 目前对PJIs的治疗方法通常受到抗生素耐药性和需要重复手术干预的限制.
研究的目的:
- 评估阴极电压控制电刺激 (CVCES) 在根除骨科植入物材料上的细菌生物膜方面的有效性.
- 评估CVCES和10%贝塔丁灌对生物膜减少的综合影响.
- 研究这些处理方法在化和无化- (CoCr) 和 (Ti) 表面的性能.
主要方法:
- 在实验室培养的E. coli,P. aeruginosa和S. aureus生物膜在固和无固的CoCr和Ti植入物表面上建立.
- 为了评估其独立的有效性,CVCES治疗被应用了24小时.
- 评估了一种3分钟10%贝塔丁治疗的组合疗法,其后是24小时的CVCES.
主要成果:
- 单靠CVCES就消除了在无水泥CoCr植入物上的*E. coli*和*P. aeruginosa*生物膜.
- 结合10%的贝塔丁和CVCES治疗使CFU水平降低到*E. coli*,*P. aeruginosa*和*S. aureus*在无植入物上的检测极限以下.
- 组合疗法是非常有效的,但不足以根除在水泥植入物上的 * S. aureus * 生物膜.
结论:
- CVCES,特别是与10%的贝塔丁结合使用时,显示出治疗骨科植入物上的生物膜感染的巨大潜力.
- 这种方法可能提供了一种新的策略,以加强目前的PJI的脱bridement,抗生素和植入物保留协议.
- CVCES是一种有前途的技术,可以改善患者在管理具有挑战性的周围假肢关节感染方面的结果.
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