[牙:发育异常的一个标志]
Muriel de La Dure-Molla1, Céline Gaucher2, Nicolas Dupré3
1Centre de référence maladies rares orales et dentaires, O-Rares, hôpital Rothschild, AP-HP, Paris ; université Paris Cité, UFR d'odontologie, Inserm, UMR1163, bases moléculaires et physiopathologiques des ostéochondrodysplasies, institut imagine, Paris ; FHU DDS Paris-Net, filière TETECOU, European Reference Network CRANIO.
Medecine sciences : M/S
|February 1, 2024
概括
牙的形成涉及复杂的上皮-介质酶相互作用,对牙发育至关重要. 异常可能表明潜在的系统性疾病影响矿物代谢,皮肤或神经系统,突出显示需要多学科护理.
科学领域:
- 发展生物学 发展生物学
- 遗传学 遗传学 是一个
- 口腔生物学 口腔生物学
背景情况:
- 牙的形成依赖于发育过程中的复杂的上皮质-介质酶相互作用.
- 牙异常可能是更广泛的全身疾病的指标,包括脏,骨,矿物代谢,皮肤或神经系统疾病.
- 牙生成是由特定的信号通路和转录因子启动的.
研究的目的:
- 阐明控制牙形成的复杂分子机制.
- 突出牙异常与全身健康之间的联系.
- 为了强调表皮细胞-介质细胞相互作用在牙生成中的作用.
主要方法:
- 复习发育生物学原理的牙生成.
- 对参与牙发育的信号通路 (如PITX2,BMP,FGF,SHH,WNT) 的分析.
- 牙异常与潜在的潜在遗传和系统性疾病的相关性.
主要成果:
- 牙的发育是由精确的上皮-介质细胞信号调节的.
- 这些相互作用的变化导致牙数量,形状和结构的变化.
- 牙异常可能作为亚临床系统性疾病的早期标志物.
结论:
- 了解牙生成是诊断和管理牙异常的关键.
- 对于牙发育缺陷的患者来说,多学科护理是必不可少的.
- 识别牙形成中的改变遗传途径可以揭示与系统性疾病的联系.
相关概念视频
01:15Teeth
424
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
424
01:21Tooth Anatomy
473
The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
473
01:26Assessment of the Mouth
214
A thorough mouth assessment, including inspection and palpation of the lips, gums, tongue, tonsils, uvula, and pharynx, is crucial in detecting potential health issues. Diseases ranging from oral cancer to systemic conditions like diabetes could be identified early through careful oral examination. This article provides a detailed guide on conducting a comprehensive mouth assessment.
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
214