胰岛素抵抗的间接指数METS-IR与肺癌风险之间的关联
Guoqing Wang1, Zhaopeng Zhu1, Yi Wang2
1Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
European journal of public health
|February 1, 2024
概括
通过METS-IR代谢得分来衡量的高胰岛素抵抗与增加肺癌风险有关. 保持较低的METS-IR可能有助于降低肺癌的长期发病率.
科学领域:
- 在瘤学瘤学.
- 代谢综合征是代谢综合征的一种.
- 流行病学 流行病学
背景情况:
- 胰岛素抵抗是众所周知的几种癌症的风险因素,包括乳腺癌,前列腺癌和结直肠癌.
- 胰岛素抵抗,遗传倾向和肺癌发展之间的关系尚未完全理解.
研究的目的:
- 调查胰岛素抵抗新型代谢得分 (METS-IR) 与患肺癌的风险之间的关联.
- 探索METS-IR与肺癌发展中的遗传风险因素之间的相互作用.
主要方法:
- 一项大型队列研究包括395,304名没有先前癌症诊断的参与者.
- 考克斯比例危险回归和门德尔随机化分析被用于评估关联和因果关系.
- 研究了METS-IR和肺癌多基因风险评分 (PRS) 之间的联合效应和相互作用.
主要成果:
- 在高METS-IR和增加肺癌风险之间发现了显著的关联 (HR:1.28,95%CI:1.17-1.41).
- 门德尔的随机化分析没有显示METS-IR和肺癌之间的因果关系.
- 在METS-IR和遗传风险之间观察到联合作用,但没有检测到添加相互作用.
结论:
- 升高的METS-IR与更高的肺癌风险显著相关.
- 保持较低的METS-IR水平可能有助于降低肺癌发病率的长期风险.
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