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基于Pyrazolopyrimidine的共价探头ZNL0325,证明了对Kinases的替代结合模式

Zhengnian Li1, Wenchao Lu2, Tyler S Beyett3,4

  • 1Department of Chemical and Systems Biology, Chem-H and Stanford Cancer Institute, Stanford School of Medicine, Stanford University, Stanford, California 94305, United States.

Journal of medicinal chemistry
|February 1, 2024
PubMed
概括

我们发现了ZNL0325,一种新型的pyrazolopyrimidine激酶抑制剂. 它以独特的翻转模式结合激酶,使共价抑制成为可能,并提供新的药物设计策略.

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DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
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