心力衰竭:来自肠道的一拳
Ajay Mahenthiran1, Jennifer Wilcox2, W H Wilson Tang3,4
1Case Western Reserve University, Cleveland, OH, USA.
Current heart failure reports
|February 1, 2024
概括
心力衰竭 (HF) 显著影响肠道微生物群,导致"漏肠". 这种肠道失调会使HF的预后恶化,强调肠道作为治疗点.
科学领域:
- 心脏病学 心脏病学
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
背景情况:
- 心力衰竭 (HF) 与肠道微生物组的改变有关.
- 脊柱血管受高血压的影响,影响肠道健康.
- "漏肠"假说表明,肠道透性增加有助于疾病.
研究的目的:
- 在心力衰竭病理生理学中阐明肠心轴的机制.
- 突出肠道失调在HF并发症和预后中的作用.
主要方法:
- 关于高频率肠心相互作用的当前研究的综述.
- 分析肠道屏障功能障碍和微生物代谢物对HF的影响.
主要成果:
- HF改变了肠道微生物组合,增加了肠道的透性.
- 特定的微生物代谢物 (SCFA,TMAO,胆酸) 与恶化HF有关.
- 肠道失调是HF预后的一个重要因素.
结论:
- 肠道微生物组及其代谢物在心力衰竭中起着至关重要的作用.
- 准肠道组成是一个有希望的治疗策略,可以改善HF的结果.
相关概念视频
Imbalances in Cardiac Output
1.4K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.4K
Pathophysiology of Heart Failure
1.6K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.6K
Anatomy of the Heart
108.7K
The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
108.7K
Heart Failure Drugs: β-Blockers
340
β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation,...
340
Cardiovascular System Abnormal Findings I: Inspection and Palpation
399
In a cardiovascular examination, inspection and palpation are crucial for identifying abnormalities.
Abnormal findings observed during an inspection
Abnormal findings observed during an inspection
399
Heart Valves
4.6K
The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
4.6K


