在西班牙队列中,肌痛性骨髓灰质炎与帕金森病并发. 是因果关系还是相关性?
Josep Gamez1,2,3,4, F Carmona5, C Lorenzo-Bosquet6,7
1Neurology Department, GMA Clinic, Barcelona, Spain. josepgamez.bcn@gmail.com.
概括
同时发生的肌痛性肌痛症 (MG) 和帕金森病 (PD) 比以前想象的更为常见. 这项研究确定了一个独特的表型,并表明这些罕见的同时发生的疾病的潜在共同病因.
科学领域:
- 神经学 神经学
- 自免疫性疾病 自免疫性疾病
- 神经退行性疾病 神经退行性疾病
背景情况:
- 已知肌痛性骨髓灰质炎 (MG) 与自身免疫性疾病的并发症.
- 同时的MG和帕金森病 (PD) 很少报告,通常被认为是巧合.
研究的目的:
- 在一个大 MG 队列中确定并发性 MG 和 PD 的频率和表型.
- 将研究结果与文献分析进行比较.
主要方法:
- 对631名MG患者同时患PD的特征.
- 对患者人口统计学,MGFA类,UPDRS得分和DaTSCAN吸收的分析.
- 发表的案件的元分析.
主要成果:
- 发现了18例同时患有MG和PD的病例.
- 现象型的特征是男性的流行,晚期发作的MG,掉头,和oculobulbar症状.
- 达斯康显示双边或单边摄入量减少.
结论:
- 同时发生的MG和PD比预期的更频繁 (2.85%).
- 这项研究表明,MG和PD的潜在共同病因.
- 需要进一步的前性研究来阐明常见的致病机制.
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