BRAF V600E突变缺乏与乳头甲状腺癌临床预后较差的关联
Hon-Fan Lai1,2, Jen-Fan Hang2,3,4, Po-Chung Kuo1,2
1Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Annals of surgical oncology
|February 1, 2024
概括
在672名患者中研究了皮肤状甲状腺癌 (PTC) 中的BRAF V600E突变. 阴性BRAF V600E瘤与更具侵略性的特征和远程转移风险增加有关.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 在乳头甲状腺癌 (PTC) 中,BRAF V600E突变的患病率各不相同.
- 关于BRAF V600E与攻击性PTC特征或预后之间的关联仍在争论中.
研究的目的:
- 调查BRAF V600E突变与PTC中的临床病理因素之间的相关性.
- 评估BRAF V600E突变与PTC患者瘤复发之间的关联.
主要方法:
- 对672名接受甲状腺手术的PTC患者 (2013-2018) 的回顾性图表审查.
- 分析BRAF V600E突变患病率及其与临床病理因素和攻击性特征 (例如,甲状腺外延伸,淋巴结转移,远程转移) 的相关性,使用费舍尔精确测试.
主要成果:
- 在672名PTC患者中,BRAF V600E突变在76.8%的患者中被检测到.
- 阴性BRAF V600E显着与较大的瘤大小,远程转移和晚期阶段 (p <0.05) 相关.
- 在BRAF V600E状态和年龄,性别,淋巴结转移,甲状腺外延伸或多中心性之间没有发现显著的关联. 在不同组之间,无病生存率相似.
结论:
- 对BRAF V600E负的乳头甲状腺癌瘤表现出更具侵略性的行为和更高的远程转移风险.
- 在PTC中BRAF V600E的预后价值仍然不确定.
- 建议进行进一步的分子分析,以了解对侵袭性瘤表型的贡献.
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