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一个高度选择性的光探测器硫化及其在活细胞中的应用

Zhiyu Ju¹, Yuxiang Zhang², Lingyu Kong²

¹Key Laboratory of Micro-Nano Materials for Energy Storage and Conversion of Henan Province, Drug Intermediates Engineering Research Center for Cleaner Production of Henan Province, College of Chemical and Materials Engineering, Xuchang University, Henan, 461000, PR China. juz1696@163.com.

Journal of fluorescence

|February 1, 2024

概括

一个新的近红外光探头DCI-H2S被开发用于敏感和选择性检测硫化 (H2S). 这个探测器在室温下提供快速检测,显示了实时生物成像的潜力.

科学领域:

化学传感器是一种化学传感器.
光探测器的光探测器
生物医学成像学生物医学成像学

背景情况:

硫化 (H2S) 是生物系统中至关重要的信号分子.
精确检测H2S对于理解其生理和病理作用至关重要.
现有的检测方法往往缺乏选择性,灵敏性或速度.

研究的目的:

为了合成和描述一种新的近红外 (NIR) 光探测器用于H2S检测.
评估探测器的性能,包括选择性,灵敏度和响应时间.
探索探测器在生物体内检测内源H2S的潜力.

主要方法:

一种基于二异索的光染料的合成,加上一种甲基3 - - - - - - - - - - - - - - 碳基 - - - - - - - - - 烯酸二烯酸反应单元.
探测器光物理性质的表征,包括辐射波长 (λem = 674 nm).
在室温下通过添加循环机制评估探针对H2S的反应.

主要成果:

合成的探头DCI-H2S在NIR区域呈现强烈的光.
DCI-H2S显示出对H2S的高度选择性和敏感性.
探测器显示在室温下对H2S的快速反应.

结论:

DCI-H2S探头是用于敏感和选择性检测H2S的有希望的工具.
它的NIR发射和快速响应促进了实时生物成像的潜在应用.
该探测器有可能在生物系统中检测内源H2S.

关键词:

光探测器探测器可以发光.硫化是一种硫化.活细胞成像活细胞成像

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