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工作记忆和焦虑之间的关系在早期治疗的基尿症 (PKU) 患者中
Kelly M Boland1, Meriah S Schoen2, Rani H Singh2
1Department of Psychological Sciences, University of Missouri.
Neuropsychology
|February 1, 2024
概括
在早期治疗的基尿症 (ETPKU) 中,焦虑会减轻工作记忆的表现. 高焦虑和氨酸 (Phe) 水平会对ETPKU患者的认知功能产生负面影响.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 早期诊断和治疗基尿 (PKU) 是至关重要的,但不能完全预防神经认知和心理问题.
- 早期接受治疗的PKU (ETPKU) 个体通常会在工作记忆 (WM) 中遇到挑战,并且有更高的焦虑风险.
研究的目的:
- 调查焦虑如何影响ETPKU和WM表现之间的关系.
- 了解焦虑在ETPKU的认知结果中的缓解作用.
主要方法:
- 一项涉及40名ETPKU成人和40名健康对照者的比较研究.
- 使用了包括基于网络的神经认知测试,采访和自我报告措施在内的远程评估方法.
- 在两组中评估了WM表现和焦虑症状.
主要成果:
- 与对照组相比,ETPKU组的WM表现明显较差.
- 虽然整体焦虑水平没有差异,但在ETPKU组中,高焦虑更为普遍 (53%对33%).
- 一个显著的相互作用表明,ETPKU和高焦虑和/或高氨酸 (Phe) 水平 (> 360μmol/L) 的个体有损害WM性能.
结论:
- 在ETPKU患者中,焦虑作用于氨水平和WM表现之间的调节者.
- 这些发现凸显了在评估和管理ETPKU患者的神经认知功能时考虑焦虑的必要性.
- 对ETPKU个体的临床和研究评估应包括焦虑评估.
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