在安大略省被诊断患有酒精使用障碍的患者中,公共资助的纳尔特雷使用模式
Nima Tourchian1, Daniel McCormack2, Pamela Leece3,4,5
1Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College St, Toronto, Ontario, M5S 3M2, Canada.
Alcohol and alcoholism (Oxford, Oxfordshire)
|February 1, 2024
概括
对酒精使用障碍 (AUD) 的纳尔特雷克松治疗显示持久性较低. 处方开始的设置没有影响持续时间,但医院启动的纳尔特雷克松与更多的补充有关.
科学领域:
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
- 成 药物 药物 药物 药物
背景情况:
- 纳尔特雷是治疗酒精使用障碍 (AUD) 的一线药物.
- 之前的研究表明,纳尔特雷克松治疗患者的延续率低于最佳.
- 了解影响纳尔特雷克森坚持的因素对于有效的AUD管理至关重要.
研究的目的:
- 为了确定在AUD患者中使用纳尔特雷的持续时间.
- 评估处方设置和停止使用纳尔特雷之间的关联.
- 为了评估现实世界人口中的药物持续性.
主要方法:
- 基于人口的回顾性队列研究.
- 利用了来自安大略省公共药物受益者的数据,诊断出AUD.
- 分析了使用Cox比例危险模型和后勤回归的纳尔特雷克松停药和处方补充的时间.
主要成果:
- 在2531名患者中,纳尔特雷使用的中位持续时间为31天.
- 只有15.6%的患者继续服用纳尔特雷克松6个月或更长时间.
- 启动设置与持续时间没有关联,但住院患者的启动与更高的补充率相关,而ED启动与较低的补充率相关.
结论:
- 在各种启动设置中,用于AUD治疗的纳尔特雷持续性仍然很低.
- 需要进一步的研究来确定治疗持久性的障碍.
- 开发以患者为中心的干预措施是改善获得基于证据的AUD治疗的关键.
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