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Updated: Jul 4, 2025

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
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A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

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在黑色素瘤中,CoREST抑制器综合体调解了表型切换和治疗耐药性

Muzhou Wu1, Ailish Hanly1, Frederick Gibson1

  • 1Department of Dermatology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA.

The Journal of clinical investigation
|February 1, 2024
PubMed
概括

向COREST表观遗传抑制器复合体,可重编程黑色素瘤细胞表型,克服对BRAF抑制剂 (BRAFi) 的耐药性. 这种方法通过逆转DUSP1下调和抑制p38 MAPK活性,使BRAFi耐药黑色素瘤重新敏感于治疗.

关键词:
皮肤病学 皮肤病学药物治疗是药物治疗.表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.黑色素瘤是一种黑色素瘤.在瘤学瘤学.

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