在长期服用氧化的患者中,评估早期视网膜变化,使用光学连贯性断层扫描,血管造影
Huanhuan Zhao1,2, Menglu Pan1, Yaping Liu3,4
1Department of Rheumatology, First Affiliated Hospital of Anhui Medical University, Hefei, China.
Therapeutic advances in drug safety
|February 1, 2024
概括
在连接组织疾病 (CTD) 中长期使用氧化 (HCQ) 与视网膜血管变化相关,可通过OCTA检测. 然而,血液中的HCQ度与这些OCTA测量的视网膜变化没有直接关联.
科学领域:
- 眼科医生 眼科 眼科
- 类风湿病学 类风湿病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 连接组织疾病 (CTD),如狼和类风湿性关节炎,通常用氧化 (HCQ) 治疗.
- 长时间使用HCQ可能会导致不良反应,特别是视网膜病变,需要监测以早期检测视网膜变化.
研究的目的:
- 在接受长期HCQ治疗的CTD患者中,使用光学连贯性断层扫描血管学 (OCTA) 识别早期视网膜变化.
- 调查OCTA参数与HCQ及其代谢物的血清度之间的相关性.
主要方法:
- 一项横截面研究涉及43名CTD患者,他们接受了HCQ治疗超过6个月.
- OCTA用于测量状血管区 (FAZ) 尺寸,斑点厚度和表面 (SCP) 和深层 (DCP) 毛细血管中的血管密度.
- 用高性能液态染色体-并联质谱法量化HCQ及其代谢物的血清度.
主要成果:
- 累计的HCQ持续时间和剂量与增加的FAZ面积和周长有正相关,并且在SCP和DCP中与状血管密度有负相关.
- 在OCTA发现与患者年龄,疾病持续时间或体重调整后的HCQ剂量之间没有发现显著的相关性.
- OCTA的结果与HCQ或其代谢物的血液度测量没有相关性.
结论:
- 在长期接受HCQ治疗的CTD患者的斑点中检测微血管变化,OCTA是一种有价值的工具.
- 目前的研究结果表明,血清中HCQ及其代谢物的度与观察到的视网膜血管变化没有直接关联.
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