带有和没有糖尿病外围神经病变的神经病变疼痛在1型糖尿病中
Barbara H Braffett1, Laure El Ghormli1, James W Albers2
1Biostatistics Center, The George Washington University, Rockville, MD.
Diabetes care
|February 1, 2024
概括
神经病痛 (NP) 在1型糖尿病 (T1D) 中很常见,通常没有明显的神经损伤迹象. 许多患者经历疼痛缓解,但对于这种常见的糖尿病外围神经病变并发症仍然需要有效的管理策略.
科学领域:
- 内分泌学和新陈代谢学
- 神经学 神经学
- 糖尿病学 糖尿病学
背景情况:
- 糖尿病外围神经病变 (DPN) 是糖尿病的一个常见并发症.
- 神经病痛 (NP) 的特征和1型糖尿病 (T1D) 的负担仍然不太清楚.
- 在T1D中NP的长期发病率,患病率和缓解需要进一步调查.
研究的目的:
- 评估长期T1D队列中NP的发病率,年度流行率,缓解和风险因素.
- 为了区分NP与或没有DPN的临床症状.
- 了解T1D中NP在延长后续期间的特征.
主要方法:
- 在EDIC研究 (1994-2020) 中使用密歇根神经病查仪器 (MNSI) 对1,324名T1D参与者的年度评估.
- 具有DPN临床症状的NP (NP DPN+) 和没有临床症状的NP (NP DPN-) 的NP的定义.
- 分析了26年的累积发病率,流行率和缓解率.
主要成果:
- 在26年后,NP的累计发病率达到57%,其中36%是NP DPN+和46%是NP DPN-.
- 在26岁时,NP的年均患病率为20% (11%的NP DPN+,9%的NP DPN-),表明经常有缓解.
- 较高的HbA1c和女性性别与NP DPN-有关,而止痛药的使用不能解释缓解.
结论:
- 在T1D中NP的高发病率,通常没有临床神经病变迹象 (MNSI).
- 观察到频繁的疼痛缓解,独立于止痛药.
- 在T1D患者中需要改进NP识别和管理的临床策略.
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