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Updated: Jul 4, 2025

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
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Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses

Published on: May 6, 2019

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慢性感染控制依赖于由N-核酸多样性产生的较低外来抗原结合强度的T细胞

Hassan Jamaleddine1, Dakota Rogers1,2, Geneviève Perreault2

  • 1Department of Physiology, McGill University, Montreal, Quebec, Canada.

PLoS biology
|February 1, 2024
PubMed
概括

终端脱核样转移酶 (TdT) 增强了T细胞受体 (TCR) 的多样性,通过包括较低亲和力的TCR来使慢性感染受益. 这有助于在高亲和性T细胞耗尽时改善病原体控制.

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Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant08:52

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

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