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Updated: Jul 4, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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关联性而不是序列的保护是光鱼中因子介导的p53/MDM2相互作用的动态演变的基础

Filip Mihalič1, Dahiana Arcila2, Mats E Pettersson1

  • 1Department of Medical Biochemistry and Microbiology, Uppsala University, BMC, Uppsala SE-75123, Sweden.

Molecular biology and evolution
|February 1, 2024
PubMed
概括

在鱼类中,p53交换活化域 (p53TAD) 和MDM2的相互作用通过重复的,融合的变化而演变. 侧边区域的补偿相互作用保持了功能结合亲和力,使预测变得复杂.

关键词:
亲和力是一种亲和力.本质上是无序的地区.蛋白质的进化 蛋白质的进化序列进化演变的过程

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