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瘤微环境在芯片上的复习:十年的进步

S M Giannitelli¹, V Peluzzi², S Raniolo¹

¹Department of Science and Technology for Sustainable Development and One Health, Università Campus Bio-Medico di Roma, via Álvaro del Portillo, 21, 00128, Rome, Italy.

|February 1, 2024

概括

开发先进的瘤微环境芯片 (TMOC) 模型克服了癌症治疗研究的局限性. 这些微生理系统为研究瘤生物学和药物反应提供了一个更准确的体外平台.

科学领域:

在瘤学瘤学.
生物技术是生物技术.
生物医学工程生物医学工程

背景情况:

目前的体外癌症模型无法复制复杂的体内瘤微环境 (TME).
三维 (3D) 文化模型比传统的二维文化提供了更好的预测价值.
微生理系统 (芯片上的器官) 正在成为研究癌症生物学的强大工具.

研究的目的:

审查10年来瘤微环境芯片 (TMOC) 模型模型模型的进展情况.
突出TMOCs在理解癌症进展,转移和药物反应方面的作用.
展示TMOC设计和整合方面的进步.

主要方法:

利用充满细胞的微流体腔和微流体封闭的瘤球体.
重新总结关键的TME组件:瘤细胞,肌层,免疫细胞和血管系统.
将TMOC集成到多器官系统中,以研究系统性影响和转移.

主要成果:

TMOCs使细胞-细胞和细胞-细胞外基质相互作用的可控,可扩展和可靠的调查.
在TMOC中的血管化对于调节细胞相互作用和调节药物药理动力学至关重要.
先进的TMOC提供了对微环境因素对瘤进展和转移的影响的新见解.

结论:

TMOCs代表了体外癌症建模的重大进步,增强了临床前研究的预测能力.
这些系统有助于发现新的治疗点,并开发更有效的抗癌疗法.
将TMOC集成到多器官系统中,为研究诸如转移和全身药物效应等复杂现象开辟了道路.

关键词:

在体外模型模型.器官在芯片上的器官瘤微环境是一个微环境.瘤球状体是指瘤的球状体.血管化血管化

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The Tumor Microenvironment

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