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基于结构的发现,发现了一系列新的核酸衍生环开放PRMT5抑制剂

Yuting Chen1, Zekun Wang2, Junjie Zhang1

  • 1Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, PR China; University of Chinese Academy of Sciences, Beijing, 100049, PR China; State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, PR China.

European journal of medicinal chemistry
|February 1, 2024
PubMed
概括

研究人员开发了新的核酸衍生物作为强大的PRMT5抑制剂用于癌症治疗. 这些化合物有效地减少了瘤细胞的增殖,并在临床前模型中显示出有前途的抗瘤疗效.

关键词:
甲基转移酶是一种甲基转移酶.核酸衍生物 核酸衍生物在PRMT5中,结构与活动的关系.

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