相关实验视频

Updated: Jul 4, 2025

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale

Published on: May 28, 2021

在牛皮患者中增加IL-31的组织表达

Rachot Wongjirattikarn¹, Nipon Chaisuriya², Suteeraporn Chaowattanapanit¹

¹Division of Dermatology, Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

|February 1, 2024

概括

与健康的皮肤相比,银病皮肤病变中的介质素-31 (IL-31) 表达显着更高. 这一发现表明IL-31在牛皮的发展中起作用,尽管与疾病的严重程度或没有直接相关.

科学领域:

皮肤病学皮肤病学
免疫学免疫学免疫学
病理生理学病理生理学

背景情况:

牛皮是一种慢性炎症性皮肤疾病,其发病因子尚未完全理解.
血清介质素-31 (IL-31) 涉及到牛皮,但其在皮肤病变中的表达未得到充分研究.
之前的研究强调了一项单一的研究,该研究是关于在损伤皮肤中对细胞病理性IL-31的表达.

研究的目的:

为了研究皮肤活检样本中的IL-31的表达,从牛皮患者与健康对照对比.
为了确定IL-31在病变表达和牛皮病的严重程度之间的相关性.
为了评估IL-31表达和牛皮患者的强度之间的关系.

主要方法:

招募牛皮病患者和健康志愿者.
从损伤皮肤 (牛皮) 和正常皮肤 (对照组) 采集4毫米孔活检.
使用免疫组织化学量化IL-31表达的量化.
分析基线特征,疾病活性,强度和实验室结果.

主要成果:

与健康皮肤相比,在表皮和皮肤牛皮病变中观察到显著增加的IL-31表达 (P < 0.001).
在病变IL-31表达和牛皮病严重程度之间没有发现统计学意义上的相关性.
病变IL-31表达与研究患者报告的强度没有显著相关.

结论:

在牛皮的皮肤病变中增加IL-31的表达,表明它参与了疾病的发病过程.
虽然IL-31在牛皮皮肤上升调节,但其表达水平似乎与疾病严重程度或没有直接关联.
需要进一步的研究来阐明IL-31在牛皮发育中的精确机制以及其作为治疗点的潜力.

关键词:

细胞因子细胞因子介质蛋白是介质蛋白中的一种.一个的.病理学病理学病理学

更多相关视频

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

Published on: April 8, 2016

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

相关概念视频

T Cell Types and Functions

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

The JAK-STAT Signaling Pathway

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...