在依赖大麻使用者中休息状态功能连接:大麻态度的调节作用
E Kroon1, Y J Toenders2, L N Kuhns1
1Neuroscience of Addiction Lab, Department of Psychology, Education & Child Studies, Erasmus University Rotterdam, the Netherlands; Department of Psychology, University of Amsterdam, Amsterdam, the Netherlands.
Drug and alcohol dependence
|February 1, 2024
概括
大麻使用者表现出大脑连接的改变,特别是在突出网络中. 个人对大麻益处和危害的看法会影响这些大脑变化和大麻使用障碍的严重程度.
科学领域:
- 神经科学是一个神经科学.
- 成研究 研究成研究
- 精神病学是一个精神病学.
背景情况:
- 全球大麻政策的转变与危害感知的减少有关.
- 减少危害感知与增加大麻使用的开始和持续性有关.
- 大麻态度对与使用相关的大脑过程的影响仍然不清楚.
研究的目的:
- 与对照组相比,研究大麻使用障碍 (CUD) 的大麻使用者休息状态功能连接 (RSFC).
- 为了检查大麻的感知好处和危害如何使用中度大脑网络连接与CUD相关.
主要方法:
- 在执行控制网络 (ECN),突出网络 (SN) 和默认模式网络 (DMN) 之间评估RSFC,对110名CUD患者和79名对照进行了评估.
- 采用了关于大麻感知益处/危害 (个人,社会,社会) 和大麻使用,CUD严重程度和相关问题的措施的问卷.
主要成果:
- 大麻使用者比对照者表现出较低的背部SN RSFC;较重的使用与背部下部SN RSFC相关.
- 在大麻使用,CUD严重程度和网络内部RSFC之间感知到的益处和危害适度的关联.
- 个人利益和社会伤害特别适度了CUD严重程度和DMN连接性之间的联系.
结论:
- 人们对大麻的危害和益处的个体差异是关键因素.
- 这些感知影响大脑功能,大麻使用,CUD严重程度和相关问题之间的关系.
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