基于加速器的体力活动与SCAPIS的8416名个体的肠道微生物群有关
Gabriel Baldanzi1, Sergi Sayols-Baixeras2, Elin Ekblom-Bak3
1Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
EBioMedicine
|February 1, 2024
概括
久坐不动的行为和体力活动对肠道微生物的影响类似,但以相反的方式. 活动强度也可能对特定的肠道细菌及其功能产生明显的影响.
科学领域:
- 微生物组研究的研究.
- 人类生理学 人类生理学
- 转基因组学是指转基因组学.
背景情况:
- 之前关于体力活动和肠道微生物群的研究依赖于自我报告,引入偏见.
- 本研究利用客观的加速度计数据进行更准确的评估.
- 研究肠道微生物群与客观测量的身体活动相关的情况.
研究的目的:
- 检查静坐行为 (SED),中等强度体力活动 (MPA) 和高强度体力活动 (VPA) 与肠道微生物群组成之间的关联.
- 探索身体活动水平与肠道微生物组的功能潜力之间的联系.
主要方法:
- 从瑞典心肺生物图像研究中对8416名参与者 (年龄在50-65岁) 的横截面分析.
- 部佩戴的加速度计测量了在SED,MPA和VPA中花费的时间.
- 枪元基因组学从便样本中分析了肠道微生物群的概况,并使用多变量回归分析.
主要成果:
- 与MPA和VPA相比,久坐不动的行为显示出与微生物丰富性的相反关联 (例如,SED的E. coli较高,MPA的E. coli较低).
- MPA和VPA与增加酸盐生产者的丰度有关,例如F. prausnitzii和Roseburia spp.
- 身体活动的强度影响了特定的微生物 (例如,与P. copri相关的MPA) 和微生物组的功能能力 (例如,乙酸合成,碳水化合物降解).
结论:
- 久坐不动的行为和体力活动与独特的肠道微生物群概况有关,在相反的方向上起作用.
- 身体活动的强度似乎调节了特定的肠道微生物物种及其代谢功能.
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