基因因被封装在β-环氧的金属有机框架中,具有高嵌入效率和稳定性
Yaqi Liu1, Chao Yuan1, Bo Cui1
1State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology, Shandong Academy of Sciences, Jinan 250353, China; School of Food Science and Engineering, Qilu University of Technology, Shandong Academy of Sciences, Jinan 250353, China.
Food chemistry
|February 1, 2024
概括
研究人员通过将其封装在β-环氧体金属有机框架 (BCDMOFs) 中,提高了apigenin的性能. 这种新的方法增强了apigenin的稳定性并控制了它的释放,提高了应用性能.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 药理学 药理学 是一个学科.
背景情况:
- 作为一种天然的黄类化合物,apigenin具有治疗潜力,但其应用性能不佳.
- 开发有效的输送系统对于提高apigenin的生物可用性和疗效至关重要.
研究的目的:
- 封装apigenin在β-cyclodextrin金属有机框架 (BCDMOFs) 中,以提高其应用性能.
- 调查BCDMOF中阿皮基宁的pH依赖封装效率和稳定性.
主要方法:
- 使用一种创新的pH调整方法,将阿皮基宁封装在BCDMOF中.
- 使用扫描电子显微镜,X射线衍射,里埃变换红外光谱学和热重力测量分析进行了生成复合材料的表征.
- 进行了储存稳定性和动力释放性研究.
主要成果:
- 在pH12下,封装效率最高达到79.2%±1.2%,显示出显著的pH依赖性.
- 鉴定证实了apigenin/BCDMOFs复合物的形成,并促进了高嵌入的孔暴露.
- 与自由阿皮根因相比,阿皮根因的稳定性在7天内增加了大约18%,这表明了增强的降解抵抗力.
结论:
- BCDMOFs有效地封装了apigenin,增强了它的稳定性并控制了它的释放.
- 开发的apigenin/BCDMOFs复合物在体外显示出更好的应用性能.
- 这项研究提出了一种有前途的策略,以改善阿皮基因的输送和疗效.
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