通过整合UHPLC-Q-Orbitrap MS化学分析和UHPLC-DAD多组分量化方法来评估西藏药品质量的综合方法Synotis solidaginea
Mengyao Wu1, Yaozu Xiong1, Lv Zhu1
1School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, Sichuan, China.
Journal of pharmaceutical and biomedical analysis
|February 1, 2024
概括
这项研究对Synotis solidaginea Hand.-Mazz.进行了全面的质量评估. (SSD),是一种西藏药用草药. 化学分析和量化发现其药用成分的区域差异很大.
科学领域:
- 植物化学 植物化学
- 分析化学 分析化学
- 药学认知是指药学上的认知.
背景情况:
- Synotis solidaginea 手的 - - 马兹. (SSD) 是一种有价值的西藏药草,具有广泛的治疗历史.
- 其显著的药用价值和利用前景需要强有力的质量控制措施.
研究的目的:
- 建立和验证SSD整体质量评估的综合战略.
- 在SSD中化学分析和量化关键组件,以评估质量变化.
主要方法:
- 使用超高性能液体染色-Q精确轨道轨道高分辨率质谱仪 (UHPLC-Q精确轨道轨道 HRMS) 进行化学分析.
- 开发并验证了一种UHPLC-二极管阵列检测 (DAD) 方法,用于量化7个特征组件.
- 采用差异分析 (ANOVA) 和Tukey的后期测试来分析组件内容的区域差异.
主要成果:
- 在SSD中确定或暂定描述了58种化合物,其中黄和有机酸是最丰富的.
- 经过验证的UHPLC-DAD方法显示出出色的线性,精度,准确性和稳定性.
- 在5个不同的生产领域的8批SSD中观察到组件含量的显著变化 (P<0.05).
结论:
- 综合的UHPLC-HRMS和UHPLC-DAD方法为SSD质量评估提供了一个全面的策略.
- 区域环境因素 (气候,海拔) 显著影响SSD的化学成分.
- 这项研究为SSD的进一步开发和质量控制提供了基础.
关键词:
化学成分 化学成分多组件定量测定 多组件定量测定这就是Synotis solidaginea.在UHPLC-DADAD中使用.在UHPLC-Q Exactive Orbitrap MS中使用.更多相关视频
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