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无症状和亚临床Mpox:与修改疫苗的关联安卡拉疫苗

Matthew R Golden, Olusegun O Soge, Margaret Mills¹

¹Laboratory Medicine and Pathology, Washington, Seattle, WA.

Sexually transmitted diseases

|February 1, 2024

概括

无症状的mopox很少见,即使在接种疫苗的人中也是如此. 修改的疫苗安卡拉 (MVA) 疫苗接种与无症状mopox感染的可能性更高有关.

科学领域:

传染性疾病传染性疾病
流行病学流行病学
疫苗学疫苗学疫苗学

背景情况:

无症状的mopox感染的患病率,特别是在接种了修饰疫苗安卡拉 (MVA) 的个人中,仍然在很大程度上是未知的.
了解无症状传播对于有效的公共卫生战略和疾病控制至关重要.

研究的目的:

为了确定无症状或亚临床mopox感染的频率.
调查MVA疫苗接种状态和症状与无症状的mpox.之间的关联.

主要方法:

莫波克斯聚合酶连锁反应 (PCR) 测试是在性健康诊所对症状和无症状患者的直肠和喉样本进行的.
数据从2022年5月到2023年5月收集,包括患者人口统计,症状和疫苗接种情况.

主要成果:

在1663名被测试的人中,1.1% (18/1689) 患有无症状或亚临床POPOX.
无症状mopox的个体显着更有可能接受至少一剂MVA疫苗 (78%对26%).
与未接种疫苗的人相比,MVA疫苗接种与无症状mopox的可能性增加了4.4至11.9倍.

结论:

无症状的mopox感染并不常见.
修改的疫苗安卡拉 (MVA) 疫苗接种与无症状或亚临床mopox感染的可能性增加有关.

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