与没有艾滋病毒的人相比,感染艾滋病毒的人的COVID-19严重程度
Vu-Thuy Nguyen1, Kshema Nagavedu1, Monica Morrison2
1Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA.
Journal of acquired immune deficiency syndromes (1999)
|February 1, 2024
概括
艾滋病毒感染者 (PWH) 面临的COVID-19严重程度和住院风险与没有艾滋病毒的人相似. 然而,CD4计数较低的PWH体验了更糟糕的结果,而计数较高的PWH体验了更好的或类似的住院率.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 艾滋病毒感染者 (PWH) 可能面临严重COVID-19的风险增加.
- 了解PWH中的COVID-19结果对于公共卫生战略至关重要.
研究的目的:
- 为了比较PWH与没有艾滋病毒的匹配个体中严重的COVID-19结果的风险.
- 调查CD4 T细胞计数对PWH中COVID-19严重性的影响.
主要方法:
- 在马萨诸塞州 (2020年3月至2022年7月) 的SARS-CoV-2成年人的回顾性队列研究.
- 使用来自三大临床实践组的电子病历数据.
- 倾向性得分匹配 (20:1) 来比较PWH和没有艾滋病毒的人之间的结果,包括严重的COVID-19,住院和住院时间.
主要成果:
- 总共有171,058名COVID-19感染者被确定;768名PWH与15360名没有艾滋病毒的人匹配.
- 在PWH和对照组中,整体严重的COVID-19和住院率在PWH和对照组之间是相似的.
- 低CD4T细胞计数 (<200细胞/毫米3) 的PWH的严重COVID-19和住院的几率明显更高 (OR分别为3.99和2.26).
- 具有高CD4计数的PWH显示住院几率较低 (OR 0.73).
结论:
- 低CD4T细胞计数的PWH经历了更糟糕的COVID-19结果.
- 与没有艾滋病毒的人相比,具有高CD4计数的PWH具有类似或更好的住院结果.
- 对于PWH访问和参与程度较低的医疗保健机构的通用性需要进一步研究.
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