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迪恩诺杰斯特不会增加粘附分子,MCP-1和人类内皮细胞中单细胞粘附的基因表达

Nanami Tahara¹, Fumitake Ito¹, Mari Kawamata¹

¹Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto, Japan Prefectural University of Medicine, Kyoto, Japan.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

|February 1, 2024

概括

迪恩诺杰斯特 (DNG) 不会增加单细胞对内皮细胞的粘附,不同于美德基酸 (MPA). 这表明DNG是激素替代疗法的更安全替代品,可能降低动脉样硬化风险.

科学领域:

内分泌学在内分泌学.
心血管研究研究心血管研究
细胞生物学细胞生物学

背景情况:

梅德罗西孕酸 (MPA) 与激素替代疗法 (HRT) 中动脉样硬化风险增加有关.
单细胞对内皮细胞的粘附是动脉样硬化的关键早期事件.
单细胞化学吸引蛋白-1 (MCP-1) 是这种粘附的关键媒介.

研究的目的:

为了评估dienogest (DNG) 作为在HRT中替代MPA的孕激素.
研究DNG对人类带静脉内皮细胞 (HUVECs) 中单细胞粘附和细胞因子表达的影响.

主要方法:

用DNG,天然孕激素或MPA治疗HUVEC,然后进行IL-1β刺激.
实时PCR用于测量粘附分子 (E-selectin,ICAM-1) 和细胞因子 (MCP-1,IL-6) 的mRNA表达.
一个流室系统评估了单细胞 (U937细胞) 粘附于HUVECs.

主要成果:

在HUVEC中,DNG没有改变E-选择素,ICAM-1,MCP-1或IL-6的表达.
MPA显著增加了单细胞对HUVECs的附着性 (p < 0.05).
在流室系统中,DNG并没有增加单细胞粘附.

结论:

迪恩诺杰斯特 (DNG) 不会影响内皮细胞激活或单细胞粘附的关键标志物.
与MPA不同,DNG不促进单细胞粘附,这表明动脉样硬化风险可能较低.
DNG值得考虑作为激素替代疗法的更安全的替代孕激素.

关键词:

这是最重要的服务.在HUVECEC中使用.在MCP-1中,MCP-1是MCP-1.粘附分子的粘附分子动脉样硬化动脉样硬化

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